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Cryogenic electron microscopy data indicate that at least for the echovirus serotype 6m, polar interactions between the 2 domain of FcRn and proteins in the viral coat may enable a viral association with the receptor at the cell surface and trigger endocytosis and a pH-dependent destabilization of the viral particle

53 These investigators noted endothelial damage with thrombus formation within 1 hour of injection, with ultimate conversion into a fibrous cord within 2 to 4 weeks

Both conditions may require corticosteroids for acute flares, immunomodulators (azathioprine, 6-mercaptopurine), and biologic therapies (anti-TNF agents, vedolizumab, ustekinumab) for moderate to severe disease

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